Solida Biotech Bioprocess Analysers
Laboratory and industrial production process control requires a fast and accurate analysis of sample to allow optimum operating conditions to be set and maintained. This can apply equally to food and beverage production, pharmaceutical products or biopharmaceutical manufacturing systems for both cell culture and microbial applications. The speed and flexibility of our enzymatic laboratory analysers makes them ideal for quality control purposes. A printed result is obtained typically within 20 – 25 seconds from sample injection. New analytical assays are continually being developed; for example measurement of methanol from dimethyl dicarbonate (DMDC) preservation of juices and other beverages but also NAD and NADH for industrial control purposes.
Available Models
OUR ANALYSERS
Offer a simple, fast and flexible method for determination of key parameters in fermentation broths, cell culture media and other microbial applications.
- BIO-GM8 industrial multi assay analyser, 11 assay test menu
- BIO-GL6 industrial multi assay analyser, 5 assay test menu
- BIO-GM10 industrial gloucose analyzer, 3 assays.
BIO-GM8 INDUSTRIAL MULTI ASSAY ANALYSER
Assays include: glucose, lactate, ethanol, methanol, ammonia, glycerol, sucrose, lactose, glutamine and NAD / NADH.
BIO-GL6 INDUSTRIAL MULTI ASSAY ANALYSER
Assays include: glucose, lactate, ethanol, methanol and glycerol.
IO-GM10 INDUSTRIAL GLUCOSE ANALYSER
Assays include: glucose.
Technical Specifications
| Available Sensors | O2/ CO2/ Ethanol/ Methanol/ CH4/ H2 |
| Accuracy | 0.2% full scale (FS) ± 3% of value |
| Concentration Range | 0 – 100 Vol.% |
|---|---|
| Measuring Principles | Infrared, Dual wavelength/ Thermal Conductivity Detector/ Zirconia dioxide or Electro chemical |
The CO2 / O2 gas sensor analyses the amount of oxygen uptake and carbon dioxide production in the outlet gas from your bioreactor or fermenter. Real-time monitoring of CO2 and O2 is a valuable tool for the measurement of cell growth within your fermenter vessels. Monitoring these changes can improve productivity by indicating the correct rates for oxygen flow and substrate feed. Using our gas analyser you can also calculate respiratory quotient (RQ), oxygen transfer rate (OTR), carbon dioxide transfer rate (CTR), and metabolic rate.
SOLIDA infrared gas analysers can be used to simultaneously measure the concentration of CH4 and H2 in sample gases. This is based on the single source two beams non dispersion infrared (NDIR) method for CH4, CO2, and the fuel cell method (ECD) for H2S and O2.
The general applications are landfill, anaerobic digestion and other fermentation processes.
Technical Specifications
| Sensor Length | 120, 225, 325, 425 mm |
|---|---|
| Diameter | 25 or 12 mm |
| Optical path length | 5 mm |
| Pressure range | 0 – 10 bar (25° C) |
| Measuring range | 0 – 2500, equivalent to total cell density of 0.5 to 100 g/L dry weight |
| Measuring principal | Absorbance |
| Wavelength |
On-line Measurement of Total Cell Density
The Solida OD-CELL sensor performs online measurement of total cell density in solution. The sensor is based on optical density, which measures the turbidity of the cell suspension. The measurement is made at NIR (near-infrared) wavelengths so it is insensitive to changes in media colour.
All particles and molecules that absorb or scatter light at 880 nm will be detected, including living and dead cells and cell debris. This measurement is effective after inoculation, when cells are expanding quickly but concentrations are low, making permittivity-based readings less reliable.
Simple online measurement of cell growth
Reliable values during the growth phase
Early detection of process deviations
Technical Specifications
| Methanol Conc. Range | 0 – 2% |
|---|---|
| Power | 24 V AC/DC adapter |
| Dimensions | 20.3 cm, 20.3 cm, 20.3 cm |
| Weight | 2.5 kg |
| Operating air pressure | 10 – 15 psig |
| Response time | 150 to 250 seconds (90% output) |
The Solida Biotech stand-alone methanol sensor provides reliable, online control of methanol concentration in cultures of pichia pastoris or other methylotrophic organisms, allowing fast and efficient optimisation of recombinant protein production. Accurate regulation of methanol concentration is necessary to maintain induction and prevent the accumulation of methanol to cytotoxic levels.
The dissolved oxygen spike method has been used to estimate the methanol concentration. However, this technique exposes the cells to potentially non-inducing levels of methanol and cannot easily be implemented with Mut- clones or with mixed substrate feeds.
Solida Biotech Methanol Sensor overcomes these limitations, giving accurate monitoring and control of methanol concentration in cultures of Mut+, Mut- and MutS recombinant pichia pastoris clones.
Key Industries
- Education & Academics
- Biopharmaceutical and Biotechnology
- Pharmaceutical
Brand
Solida Biotech is a dynamic company that specializes in engineering, developing, and manufacturing innovative bioprocess equipment.
The company was founded by a management team with over 20 years’ experience in the fields of fermentation, cell culture, sterile processing, software and automation technologies, with the aim of meeting the challenges of producing and supplying leading industrial and institutional customers with a new generation of bioreactors and fermenters for research and production, as well as scientific instruments.